CPI optimises development of novel biotherapeutics with BioStreamline project

CPI, a UK-based technology innovation centre and a founding member of the High Value Manufacturing Catapult based at NETPark, has recently disseminated the results of the £11.2 million BioStreamline project to optimise the development of novel biotherapeutics.

The project focused on accelerating the discovery and development of monoclonal antibodies and aimed to overcome key bottlenecks in the biologics supply chain. By improving biologics production, superior drugs can be identified earlier which will lead to more efficient development and manufacture of biologics.

The collaborative project brought together a number of partner organisations across the spectrum of drug discovery and development, including Lonza Biologics, UCB Celltech, Sphere Fluidics Ltd, Horizon Discovery Group plc, Alcyomics Ltd and CPI. Funding for the project was provided by the UK Government’s Advanced Manufacturing Supply Chain Initiative (AMSCI).

A dissemination event took place on the 26th June 2019, showcasing a number of results from the project and discussing the potential impact on overcoming some of the most significant shortcomings of the biologics supply chain. One of the key deliverables of the project was the development of Sphere Fluidics’ Cyto-Mineâ Single Cell Analysis System and its associated workflows. The microfluidic picodroplet technology of Cyto-Mine® enables the screening of B-cells during antibody discovery and analysis of antibody-producing clones for selection of high-producing cell lines during cell line development. Cyto-Mine® has now been supplied to international biopharma companies and contract manufacturing organisations (CMOs) and is currently producing promising results in reducing cell line development timelines. This, in turn, will increase the speed and efficiency of novel drugs entering the biologics supply chain.

Another key deliverable of the project has been in the expression and purification of more than 50 monoclonal antibodies (mAbs) using industry-leading platforms. The biochemical, biophysical and stability data collected on each of these molecules has contributed to the design of a developability tool which will enable more accurate decision-making during process development. Although these methodologies were developed for mAbs, they could also be applicable to other emerging therapeutic modalities such as antibody drug conjugates, bispecifics and viral vectors.

In addition to the achievement of these key project outcomes, CPI also created seven new jobs with roles in line with the project commitments. Further to this, three employees were seconded to UCB and Lonza to gain experience and expertise in molecular biology, upstream processing and analytical assessment. The skills gained during this time were then used in the BioStreamline project on their return to CPI.

John Liddell, Chief Technologist, CPI, said: “It is exciting to see the outcomes of this project and the impact it will have on both the biotherapeutics industry and society as a whole. The BioStreamline project has also been extremely successful from a CPI perspective, enabling the enhancement of our experience and expertise around upstream and downstream workflows, analytics, mass spectrometry, data analysis and data modelling.”

Lucy French, Operation Manager, Alcyomics, said: “The BioStreamline project has allowed companies to bring together their expertise and work towards the common goal of streamlining the biologics supply chain. As part of the project team, Alcyomics have developed a unique human in vitro assay that will enable high throughput screening at the early stages of development, allowing identification and elimination of those therapeutics that are likely to cause an adverse effect. The novel assay will not only reduce product development costs and timelines, but also predict  the occurrence of systemic adverse immune reactions.”

Dr Rob Marchmont, Vice President of Sales and Marketing, Sphere Fluidics, said: “We are delighted at the outcomes of the BioStreamline project. The development of the Cyto-Mine® platform provides the crucial acceleration needed in monoclonal antibody development and production. Deploying Cyto-Mine® in the biologics area significantly improves efficiencies and reduces timelines in the development workflow and therefore will boost the entry of biologics into the supply chain. Overall this has the potential to have a huge impact on the way biotherapeutics are produced in the UK.”

News source: CPI

CPI Lab

Follow NETPark On Social Media

Keep up to date with the latest NETPark news and events.

NETPark Logo

The North East Technology Park provides a dynamic and supportive environment to accelerate the growth of ambitious, innovative, high tech companies into global markets. NETPark encourages collaborative multidisciplinary links, driving innovation, enterprise and economic prosperity.
We provide companies with access to a focused and international community where talent flourishes, ideas are generated and businesses have the support and resources to compete with the best in the world.

NETPark North East Technology Park

NETPark, North East Technology Park,
Sedgefield, County Durham TS21 3FD

Call Us: (+44) 01740 625250
Email: enquiries@northeasttechnologypark.com
Web: northeasttechnologypark.com

The quality of the facilities at NETPark and the attitude of staff is first class. It has a really dynamic, innovative atmosphere.

Dr Neil Loxley, - Chief executive, IBEX

The proximity to the universities and the infrastructure are very important factors. Ultimately having a presence in Europe is very valuable to us and we intend to stay at NETPark for many years to come.

Dr Arnab Basu, - CEO, Kromek

When looking for premises which would support our growth, whilst we’d looked at other locations nothing came close to NETPark. The office is modern and well serviced and reflects the type of company we are.

Paul Ashley , - Co-Founder, PNTS

We’re delighted to have opened our new site at NETPark.  This will make it easier for us to attract the best engineering talent to the Tharsus team so that we can continue to deliver game-changing robotic systems for our customers.

Brian Palmer , - CEO, Tharsus

We initially came because of the printable electronics centre but access to a highly skilled semi conductor workforce in the North East has been a key factor in us staying and growing here, as well as the value for money office space and the access to funding.

Ken Williamson, - COO, PragmatIC Printing

CPI has developed a specialist offering to support SMEs looking to develop their printable electronics applications and our partnership with Business Durham has been instrumental in attracting several SMEs to locate here in the region.

Dr Jon Helliwell, - Director of Printable Electronics, CPI

It fits perfectly for us that we’re surrounded by like-minded companies at NETPark. There are a number of highly skilled people in the area who can help us grow our business. The facilities and services offered by NETPark are first class, they make office life simple and engaging.

Stuart Wilson, - CEO, Ascarii

Access to quality facilities was one of the main drivers for deciding to locate the business at the NETPark. We have been able to use this as a launch pad to link into support from CPI and world-class expertise from Durham University.

Steve Clements, - Managing Director, aXenic
2019-09-24T11:31:18+00:00